Drug Name Atarax

The active group of L, S, P, and F (or their metabolites) resembles that of the physiological substrate of the enzyme (A). L and S are lactones that are rapidly absorbed by the enteral route, subjected to extensive first-pass extraction in the liver, and there hydrolyzed into active metabolites.
The resulting striatal dopamine deficiency leads to overactivity of cholinergic interneurons and imbalance of striopallidal output pathways, manifested by poverty of movement (akinesia), muscle stiffness (rigidity), tremor at rest, postural instability, and gait disturbance. Pharmacotherapeutic measures are aimed at restoring dopaminergic function or suppressing cholinergic hyperactivity.

 

Because digestion of food in the intestinal tract is dispensable and only counterproductive, the propulsion of intestinal contents is slowed to the extent that peristalsis diminishes and sphincteric tonus increases. However, in order to increase nutrient supply to heart and musculature, glucose from the liver and free fatty acid from adipose tissue must be released into the blood.
If feasible, this approach is preferred because all pharmacotherapeutic measures entail significant adverse effects. Migraine is a syndrome characterized by recurrent attacks of intense headache and nausea that occur at irregular intervals and last for several hours.